Я хочу проапдейтить пост про ДГМ, но ни один из нейронов сейчас не в состоянии взяться за этот черный и неблагодарный труд. Но хочу поддержать мой зимний, кажется, тренд по посту в день хотя бы в течение недели. Так что придется потерпеть.
Старый хороший флешмоб из черновиков:
My Favorite Things about Chemistryчитать дальше1. Pretty/sharp NMR spectra
2. Colorful compounds: pink, red, purple, bright yellow etc
3. Sparkly compounds and crystals
4. Mixing acids and bases together - it gets all foamy and stuff
5. Setting up any kind of purification apparatus. Because target compound NMR is so pretty after a successful purification
6. Drawing reaction mechanisms
7. Dimroth condensers
8. Purple nitrile gloves
9. Multi-step syntheses with good yields
10. Absorption spectroscopy - the spectra look so squiggly and all
Notice the absence of any liquid nitrogen/dry ice references! :) Самые любимые абстракты из
Journal of Unpublished Chemistry. Пусть повисит для поднятия настроения. :)
The total synthesis of triethyl ammonium hydrobromide from expensive, difficult to prepare starting materials. Triethyl ammonium hydrobromide was synthesised in excellent yield from N-tertbutyldimethylsilanyl-4-bromo azetidinone in a single step
Experimental details:
To a stirred, -78°C, 0.2M solution of N-tertbutyldimethylsilanyl-4-bromo azetidinone in THF (0.5g, 1.894mM in 10ml), was added triethylamine (0.26ml, 1.894mM). Thioacetic acid (0.14g, 1.894mM) was added dropwise over 20 minutes forming a pale yellow solution, before the reaction mixture was allowed to warm to ambient temperature over 2 hours and the solvent removed by reduced pressure rotary evaporation. Ice cold diethyl ether (25ml) was added with trituration causing precipitation of the product as pale yellow crystals (0.32g, 93%, mp: 181-183°C).
"Never Start a Column After 4 pm": Superstition or Sense? The efficacy of silica chromatography in the late afternoon was investigated on all five weekdays, and Saturday.
Synthesis of Coal From Vitamin B12. CCS
Total Synthesis of Vitamin B12 From Coal. An extensive study in futility as your supervisor wouldn't buy you that oh-so important starting material.
Dr R. UK
читать дальше#2Quantum Tunnelling: Particles in Sealed Glass Bottles.
Analysis of the vapour component of several chemical storage cupboards led to the conclusion that quantum tunnelling effects act on the macroscopic scale.
CS, UK
Upon Cleaning Glassware: Chromic Acid or "Smash-it-and-bin-it"?
Chromic acid is often the last resort for stubborn contamination on glassware. However, the option of smashing the apparatus, and disposing of it as waste glass, is often overlooked. The merits of both techniques are discussed in this communication.
Solid Phase Extraction Techniques: The use of Cellulose to Extract Valuable Product from the Laboratory Floor.
Includes a useful table of solvents suitable for contaminating your product with blue dye pigments.
WB, Sweden
Review: The Refrigerator Rearrangement Reaction in Organic Synthesis.
A review highlighting the interesting decompositions that can happen following the storage of compounds overnight in a refrigerator. The Refrigerator Rearrangement normally follows after a 15 step synthesis to a crucial intermediate during doctorate work. We compared Smeg, Westinghouse, GE, Samsung and Bosch.
DM, UK